A Brief and Feasible Paper-Based Method to Screen for Neurocognitive Impairment in HIV-Infected Patients: The NEU Screen | Fundació Lluita contra la Sida

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A Brief and Feasible Paper-Based Method to Screen for Neurocognitive Impairment in HIV-Infected Patients: The NEU Screen

15/08/2013

Autors: Jose A. Muñoz-Moreno, PhD, Anna Prats, MS, Núria Pérez-Álvarez, MS, Carmina R. Fumaz, PhD, Maite Garolera, PhD, Eduardo Doval, PhD, Eugènia Negredo, PhD, Maria J. Ferrer, MS, and Bonaventura Clotet, PhD, for the NEU Study Group

Revista: JAIDS (Journal of Acquired Immune Deficiency Syndromes)

2013 Aug 15;63(5):585-92. doi: 10.1097/QAI.0b013e31829e1408.

OBJECTIVE:
Practical screening methods are necessary to detect neurocognitive impairment (NCI) in HIV-infected patients. We aimed to find a brief and feasible paper-based tool to facilitate the diagnosis of an HIV-associated neurocognitive disorder.
METHODS:
A total of 106 HIV-infected outpatients with variable clinical characteristics were recruited in a multicenter investigation. NCI was diagnosed using a standardized neuropsychological tests battery (7 areas, 21 measures, ;2 hours). Multiple score combinations were compared to find a paper-based method that took #10 minutes to apply. The presence of NCI was considered the gold standard for comparisons, and the sensitivity and specificity were calculated.
RESULTS:
Subjects were mostly middle-aged (median, 44 years) men (87%) on antiretroviral treatment. NCI was detected in 51 individuals (48%) and was associated with lower nadir CD4 count (P, 0.001), receiving antiretroviral therapy (P = 0.004), fewer years of education (P = 0.009), and presence of comorbidities (P , 0.001). The score combination that showed the highest sensitivity (74.5%) and specificity (81.8%) detecting NCI included 3 measures of attention/working memory, executive functioning, and verbal fluency (part A of Trail Making Test, part B of Trail Making Test, and Controlled Oral Word Association Test scores). A broader paperbased selection of measures covering 7 areas indicated a sensitivity of 100% and a specificity of 96.3% (7 measures, ;35 minutes).
CONCLUSIONS:
The combination of the 3 measures presented in this study seems to be a rapid and feasible screening mean for NCI in HIVinfected patients. This approach, combined with screening for potential comorbidities and daily functioning interference, could help in the initial stages of a HIV-associated neurocognitive disorder diagnosis and in settings with limited access to neuropsychological resources.