Long-term Effectiveness of Recommended Boosted PI-Based Antiretroviral Therapy in Europe | Fundació Lluita contra la Sida

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PUBLICACIONS CIENTÍFIQUES > Long-term Effectiveness of Recommended Boosted PI-Based Antiretroviral Therapy in Europe

Long-term Effectiveness of Recommended Boosted PI-Based Antiretroviral Therapy in Europe

05/06/2014

Autors: JR Santos, A Phillips, S De Wit, C Pedersen, P Reiss, A Blaxhult, A Lazzarin, R Paredes, JD Lundgren, and Alessandro Cozzi-Lepri, on behalf of EuroSIDA inEuroCOORD

Background
The efficacy and safety profiles of current boosted PI have extensively been studied in clinical trials, but data on long term effectiveness of regimens containing ATV/r, DRV/r, and LPV/r are limited. Furthermore, it is important to assess the impact of boosted PI in unselected HIV-infected patients because the efficacy of therapy in daily clinical practice clearly differs from the high rates of success observed in clinical trials.
The aim of this study was to evaluate the long-term effectiveness of ATV/r, DRV/r, and LPV/r-containing regimens in a large European cohort of patients. In addition, we evaluate factors associated with virological and treatment outcomes in the clinical setting.